Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma

Table 3

Comparison of risk factors associated with reduced glomerular filtration rate estimated by CKD-EPI-creatinine and cystatin C.

	CKD-EPI-CysC		value	CKD-EPI-sCr		value
	eGFR <60	eGFR >60		eGFR <60	eGFR >60
Number of patients (%)	35 (57)	26 (43)		21 (34)	40 (66)
Number of women (%)	14 (40)	10 (38)	0.924	6 (28.6)	18 (45)	0.819
Mean age (years ± SD)	71 ± 11	64 ± 10	0.013	72 ± 12	66 ± 9	0.0317
β-2-Microglobulin >3.5 mg/L	29 (83)	9 (35)	0.018	20 (95)	18 (45)	0.023
	8.9 ± 6.3	3.38 ± 1.47	0.0001	10.9 ± 6.9	4.2 ± 2.2	<0.0001
Hemoglobin <10 g/dL	14 (40)	4 (15)	0.740	9 (43)	9 (22)	0.769
	10.4 ± 1.9	12.6 ± 2.7	0.0004	10.5 ± 1.97	11.8 ± 2.6	0.0495
Serum urate (mg/dL)	7.1 ± 2.7	5.7 ± 1.81	0.025	8.4 ± 2.5	5.5 ± 1.7	<0.0001
Mean urine monoclonal component (g/L) (95% CI)	0.2 (0.07–0.54)	0.015 (0–0.12)	0.003	0.32 (0.07–0.84)	0.03 (0–0.12)	0.0021
Mean 24 h-urine proteinuria (g/L) (95% CI)	0.53 (0.25–1.29)	0.21 (0.09–0.31)	0.004	1.24 (0.29–1.84)	0.23 (0.11–0.39)	0.0002
Albumin <35 g/L	21 (60)	5 (14)	0.176	9 (43)	19 (47.5)	0.854
	34.1 ± 6.8	38.05 ± 4.77	0.0137	34.8 ± 6.5	36.6 ± 6	0.31
R-ISS-3	13 (37.1)	1 (3.8)	0.002	10 (47.6)	4 (10)	0.003