Safety and Efficacy of Subcutaneous Rituximab in Previously Untreated Patients with CD20+ Diffuse Large B-Cell Lymphoma or Follicular Lymphoma: Results from an Italian Phase IIIb Study
Table 4
Treatment-related TEAEs by preferred term. Data are number (%) of patients [number of events].
All patients (N = 158)
DLBCL (N = 72)
FL (N = 86)
Neutropenia
14 (8.9%) [18]
5 (6.9%) [6]
9 (10.5%) [12]
Erythema
5 (3.2%) [5]
0 (0.0%) [0]
5 (5.8%) [5]
Leukopenia
5 (3.2%) [7]
1 (1.4%) [1]
4 (4.7%) [6]
Injection site erythema
3 (1.9%) [4]
0 (0.0%) [0]
3 (3.5%) [4]
Pyrexia
3 (1.9%) [3]
2 (2.8%) [2]
1 (1.2%) [1]
Lymphopenia
3 (1.9%) [5]
0 (0.0%) [0]
3 (3.5%) [5]
Influenza-like illness
2 (1.3%) [2]
0 (0.0%) [0]
2 (2.3%) [2]
Herpes virus infection
2 (1.3%) [2]
0 (0.0%) [0]
2 (2.3%) [2]
Neutrophil count decreased
2 (1.3%) [2]
2 (2.8%) [2]
0 (0.0%) [0]
Rash
2 (1.3%) [3]
1 (1.4%) [2]
1 (1.2%) [1]
Anaemia
1 (0.6%) [1]
1 (1.2%) [1]
Febrile neutropenia
1 (0.6%) [1]
1 (1.4%) [1]
Hypoglubulinaemia
1 (0.6%) [1]
1 (1.4%) [1]
Thrombocytopenia
1 (0.6%) [1]
1 (1.4%) [1]
Diarrhoea
1 (0.6%) [1]
1 (1.4%) [1]
Paraesthesia oral
1 (0.6%) [4]
1 (1.4%) [4]
Administration site pain
1 (0.6%) [1]
1 (1.4%) [1]
Inflammation
1 (0.6%) [1]
1 (1.2%) [1]
Injection site oedema
1 (0.6%) [1]
1 (1.2%) [1]
Injection site rash
1 (0.6%) [1]
1 (1.2%) [1]
Injection site swelling
1 (0.6%) [1]
1 (1.2%) [1]
Oedema
1 (0.6%) [1]
1 (1.2%) [1]
Hypertransaminasemia
1 (0.6%) [1]
1 (1.4%) [1]
Folliculitis
1 (0.6%) [1]
1 (1.2%) [1]
Herpes zoster
1 (0.6%) [1]
1 (1.2%) [1]
Klebsiella infection
1 (0.6%) [1]
1 (1.4%) [1]
Pneumocystis jirovecii infection
1 (0.6%) [1]
1 (1.2%) [1]
Pneumonia
1 (0.6%) [1]
1 (1.4%) [1]
Upper respiratory tract infection
1 (0.6%) [1]
1 (1.2%) [1]
Vulvovaginitis
1 (0.6%) [1]
1 (1.2%) [1]
Gout
1 (0.6%) [1]
1 (1.2%) [1]
Hypokalaemia
1 (0.6%) [1]
1 (1.4%) [1]
Hyponatraemia
1 (0.6%) [1]
1 (1.2%) [1]
Paraesthesia
1 (0.6%) [1]
1 (1.4%) [1]
Chylothorax
1 (0.6%) [1]
1 (1.4%) [1]
N: number of patients; TEAE: treatment-emergent adverse event; DLBCL: diffuse large B-cell lymphoma; FL: follicular lymphoma.
