Association of Pulmonary Hypertension and Monoclonal Gammopathy of Undetermined Significance
Table 3
Frequency of MGUS diagnosis among 222 PH cases using restrictive right heart catheterization criteria and their matched controls.
End of interval
Controls
PH cases
Conditional logistic regression
N†
#
(%)
N†
#
(%)
OR
(95% C.I.)
Index date + 30 days
All ages
222
4
(1.8)
222
14
(6.3)
3.50
(1.15, 10.63)
0.027
≤49
43
0
(0.0)
43
1
(2.3)
50–59
45
0
(0.0)
45
3
(6.7)
60–69
57
1
(1.8)
57
2
(3.5)
70–79
50
2
(4.0)
50
3
(6.0)
80–89
26
1
(3.8)
26
5
(19.2)
≥90
1
0
(0.0)
1
0
(0.0)
Index date + 5 years
All ages
222
4
(1.8)
222
23
(10.4)
5.75
(1.99, 16.27)
0.001
≤49
43
0
(0.0)
43
2
(4.7)
50–59
45
0
(0.0)
45
5
(11.1)
60–69
57
1
(1.8)
57
4
(7.0)
70–79
50
2
(4.0)
50
5
(10.0)
80–89
26
1
(3.8)
26
7
(26.9)
≥90
1
0
(0.0)
1
0
(0.0)
Index date + 10 years
All ages
222
5
(2.3)
222
25
(11.3)
5.00
(1.91, 13.06)
0.001
≤49
43
0
(0.0)
43
2
(4.7)
50–59
45
0
(0.0)
45
5
(11.1)
60–69
57
1
(1.8)
57
5
(8.1)
70–79
50
2
(4.0)
50
6
(12.0)
80–89
26
2
(7.7)
26
7
(26.9)
≥90
1
0
(0.0)
1
0
(0.0)
Ever diagnosed‡
All ages
222
6
(2.7)
222
27
(12.2)
4.50
(1.86, 10.90)
0.001
≤49
43
0
(0.0)
43
2
(4.7)
50–59
45
0
(0.0)
45
5
(11.1)
60–69
57
2
(3.5)
57
7
(12.3)
70–79
50
2
(4.0)
50
6
(12.0)
80–89
26
2
(7.7)
26
7
(26.9)
≥90
1
0
(0.0)
1
0
(0.0)
For the primary analysis, MGUS diagnoses made prior to the index date + 30 days were included. Since screening for MGUS was not performed routinely, sensitivity analyses were performed which used various extended time intervals when identifying patients with a diagnosis of MGUS. Since MGUS diagnoses were only available through 12/31/2017, the duration of the extended intervals was truncated for some patients. † Number of PH cases and controls in the given age category. ‡ Any MGUS diagnosis prior to 12/31/2017. Conditional logistic regression taking into account the 1:1 matched set study design.
