Table of Contents Author Guidelines Submit a Manuscript
Advances in Medicine
Volume 2016, Article ID 3917916, 9 pages
http://dx.doi.org/10.1155/2016/3917916
Research Article

CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration

1Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania
2Neuroscience Institute, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania
3Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy, Eiveniu 2, LT-50009 Kaunas, Lithuania

Received 13 April 2016; Revised 23 July 2016; Accepted 26 July 2016

Academic Editor: Xinhua Shu

Copyright © 2016 Ruta Sakiene et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Age-related macular degeneration is the leading cause of blindness in elderly individuals where aetiology and pathophysiology of age-related macular degeneration are not absolutely clear. Purpose. To determine the frequency of the genotype of rs2108622 in patients with early and exudative age-related macular degeneration. Methods. The study enrolled 190 patients with early age-related macular degeneration, 181 patients with exudative age-related macular degeneration (eAMD), and a random sample of 210 subjects from the general population (control group). The genotyping of rs2108622 was carried out using the real-time polymerase chain reaction method. Results. The analysis of rs2108622 gene polymorphism did not reveal any differences in the distribution of C/C, C/T, and T/T genotypes between the early AMD group, the eAMD group, and the control group. The CYP4F2 (1347C>T) T/T genotype was more frequent in males with eAMD compared to females (10.2% versus 0.8%; ); also T/T genotype was less frequently present in eAMD females compared to healthy control females (0.8% versus 6.2%; ). Conclusion. Rs2108622 gene polymorphism had no predominant effect on the development of early AMD and eAMD. The T/T genotype was more frequent in males with eAMD compared to females and less frequently present in eAMD females compared to healthy females.