CYP4F2 (rs2108622) Gene Polymorphism Association with Age-Related Macular Degeneration
Table 5
Frequency of CYP4F2 rs2108622 genotype in the patients with early AMD and eAMD and the control subjects by gender.
Genotype
Males
value
Females
value
AMD group (%)
Control group (%)
AMD group (%)
Control group (%)
Frequency of CYP4F2 (1347C>T; V433M) rs2108622 genotype in the patients with early age-related macular degeneration (AMD) and the control subjects by gender
TT
6 (10.5)
6 (12.2)
0.149
5 (3.8)
10 (6.2)
0.429
TC
27 (47.4)
23 (46.9)
1
54 (40.6)
59 (36.6)
0.547
CC
24 (42.1)
20 (40.8)
1
74 (55.6)
92 (57.1)
0.814
Allele
T
39 (34.51)
35 (35.71)
64 (24.06)
79 (24.53)
C
75 (65.49)
63 (64.29)
202 (75.94)
243 (75.47)
Frequency of CYP4F2 (1347C>T; V433M) rs2108622 genotype in the patients with exudative age-related macular degeneration (AMD) and the control subjects by gender
TT
6 (10.2)
6 (12.2)
0.767
1 (0.8)
10 (6.2)
0.027
TC
22 (37.7)
23 (46.9)
0.333
50 (41.0)
59 (36.6)
0.462
CC
31 (52.5)
20 (40.8)
0.250
71 (58.2)
92 (57.1)
0.904
Allele
T
34 (28.81)
35 (35.71)
50 (20.66)
79 (24.53)
C
84 (71.19)
63 (64.29)
192 (79.34)
243 (75.47)
. value: significance level (alpha = 0.05); value HWE: significance level (alpha = 0.05) by Hardy-Weinberg equilibrium.
