Research Article
Evaluation of HLA-G 14 bp Ins/Del and +3142G>C Polymorphism with Susceptibility and Early Disease Activity in Rheumatoid Arthritis
Table 1
Association of HLA-G polymorphisms and the risk of RA.
| | HLA-G polymorphisms | Case
(%) | Control
(%) | OR (95% CI) | | |
| | 14-bp ins/del (rs66554220) | | | | | | | Codominant | | | | | | | Ins/ins | 36 (18.6) | 34 (21.5) | 1.00 | — | | | Ins/del | 123 (63.4) | 97 (61.4) | 1.20 (0.70–2.05) | 0.582 | 1.00 | | Del/del | 35 (18.0) | 27 (17.1) | 1.22 (0.62–2.43) | 0.603 | 1.00 |
| | Dominant | | | | | | | Ins/ins | 36 (18.6) | 34 (21.5) | 1.00 | | | | Ins/del + del/del | 158 (81.4) | 124 (78.5) | 1.20 (0.71–2.03) | 0.505 | 1.00 |
| | Recessive | | | | | | | Ins/ins + ins/del | 159 (82.0) | 131 (82.9) | 1.00 | | | | Del/del | 35 (18.0) | 27 (17.1) | 1.07 (0.61–1.86) | 0.888 | 1.00 |
| | Allele | | | | | | | Ins | 195 (50.3) | 165 (52.2) | 1.00 | — | | | Del | 193 (49.7) | 151 (47.8) | 1.08 (0.80–1.46) | 0.649 | 1.00 |
| | +3142G>C (rs1063320) | | | | | | | Codominant | | | | | | | GG | 135 (69.6) | 89 (56.3) | 1.00 | — | | | GC | 52 (26.8) | 56 (35.4) | 0.61 (0.38–0.97) | 0.038 | 0.076 | | CC | 7 (3.6) | 13 (8.2) | 0.36 (0.14–0.92) | 0.034 | 0.068 |
| | Dominant | | | | | | | GG | 135 (69.6) | 89 (56.3) | 1.00 | | | | GC + CC | 59 (30.4) | 69 (43.7) | 0.56 (0.36–0.87) | 0.011 | 0.022 |
| | Recessive | | | | | | | GG + GC | 187 (96.4) | 145 (91.8) | 1.00 | | | | CC | 7 (3.6) | 13 (8.2) | 0.42 (0.16–1.07) | 0.068 | 1.00 |
| | Allele | | | | | | | G | 322 (83.0) | 234 (74.0) | 1.00 | — | | | C | 66 (17.0) | 82 (26.0) | 0.58 (0.41–0.84) | 0.004 | 0.005 |
|
|
: Bonferroni-corrected .
|
