Antifungal Susceptibility Patterns of Candida Species Recovered from Endotracheal Tube in an Intensive Care Unit

Table 1

In vitro susceptibilities of Candida spp. recovered from endotracheal tube to antifungal agents. MIC range, geometric mean, MIC₅₀, and MIC₉₀ values are expressed in μg/mL.

Species ()	Antifungal agents	Ranges	MIC50	MIC90	GM
Total Candida spp. (95)	Amphotericin B	0.062–4	1	2	0.420
	Itraconazole	0.016–≥16	0.75	4	0.847
	Voriconazole	0.016–≥16	0.25	4	0.381
	Fluconazole	0.016–≥64	4	64	2.881
	Caspofungin	0.008–2	0.5	0.5	0.294
C. albicans (34)	Amphotericin B	0.062–2	0.5	2	0.178
	Itraconazole	0.016–≥16	0.062	16	0.242
	Voriconazole	0.016–≥16	0.031	8	0.119
	Fluconazole	0.016–≥64	0.5	8	0.999
	Caspofungin	0.008–0.5	0.5	0.5	0.182
C. glabrata (24)	Amphotericin B	0.062–2	1	2	0.706
	Itraconazole	0.016–16	8	16	3.121
	Voriconazole	0.016–16	0.5	16	0.684
	Fluconazole	0.25–16	16	64	5.941
	Caspofungin	0.125–1	0.5	0.75	0.390
C. parapsilosis (16)	Amphotericin B	0.016–1	0.25	0.5	0.158
	Itraconazole	0.016–0.5	0.5	0.5	0.249
	Voriconazole	0.016–0.5	0.125	0.25	0.157
	Fluconazole	0.125–4	2	2	1
	Caspofungin	0.125–0.5	0.5	0.5	0.314
C. tropicalis (12)	Amphotericin B	1–4	2	4	2
	Itraconazole	1–≥64	16	16	7.245
	Voriconazole	0.125–4	2	2	1
	Fluconazole	4–≥64	16	—	19.02
	Caspofungin	0.008–2	0.5	0.5	0.458
C. krusei (9)	Amphotericin B	0.062–2	2	—	0.447
	Itraconazole	0.031–8	0.37	—	0.398
	Voriconazole	0.125–16	0.25	—	0.870
	Fluconazole	0.016–4	32	—	2.512
	Caspofungin	0.008–2	0.375	—	0.353

GM: geometric mean.