Review Article
Methylene Blue Effectiveness as Local Analgesic after Anorectal Surgery: A Literature Review
Table 1
Critical appraisal of the studies.
| Articles | Years | Validity | Relevance | Study design | Number of patients | Randomization | Similarity treatment & control | Blinding | Comparable treatment | Intention to treat | Determinant | Measurement of outcome | Level of evidence |
| Xiang and Feng [6] | 2015 | Retrospective study (case-control) | 151 | − | + | − | + | − | + | + | 4 | Sim and Tan [1] | 2013 | Randomized single-blind clinical trial | 67 | + | + | + | + | − | + | + | 2 | Samalavicius et al. [9] | 2012 | Prospective study (case series follow-up) | 10 | − | + | − | − | − | − | + | 4 | Sutherland et al. [10] | 2009 | Prospective study (case series follow-up) | 49 | − | + | − | − | − | − | + | 4 |
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