The Synergistic Antitumor Effect of Tanshinone IIA Plus Adriamycin on Human Hepatocellular Carcinoma Xenograft in BALB/C Nude Mice and Their Influences on Cytochrome P450 CYP3A4 <i>In Vivo</i>

<div>Effects of Tan IIA on liver tissue induced hepatotoxicity in histological appearance by ADM in HepG2 tumor-bearing mice (magnification, ×100 and ×400 as indicated). (a) Inflammatory cells infiltration around the central lobular vein. (b) Local hepatocyte necrosis. (c) Hepatic sinusoid congestion (indicated by arrowheads).</div>

Advances in Medicine

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Figure 5

Figure 5: The Synergistic Antitumor Effect of Tanshinone IIA Plus Adriamycin on Human Hepatocellular Carcinoma Xenograft in BALB/C Nude Mice and Their Influences on Cytochrome P450 CYP3A4 <i>In Vivo</i> 

Figure 5 | The Synergistic Antitumor Effect of Tanshinone IIA Plus Adriamycin on Human Hepatocellular Carcinoma Xenograft in BALB/C Nude Mice and Their Influences on Cytochrome P450 CYP3A4 In Vivo 