The Role of Gut Microbiome Perturbation in Fatigue Induced by Repeated Stress from Chemoradiotherapy: A Proof of Concept Study

Figure 3

Boxplots showing the relative abundance of selected genera between fatigued and nonfatigued groups (No/= nonfatigued; Yes = fatigued) based on Mann–Whitney U test in fecal samples at the middle of treatment ((a) Ruminococcus, (b) Akkermansia, (c) Oscillospira, and (d) Escherichia genus) and at the end of treatment ((e) Oscillospira, (f) Bacteroides, (g) Faecalibacterium, and (h) Lactobacillaceae) relative to baseline, pre-CRT. Middle of treatment (fatigued n = 13; nonfatigued n = 13); end of treatment (fatigued n = 15; nonfatigued n = 7).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)