The Role of Gut Microbiome Perturbation in Fatigue Induced by Repeated Stress from Chemoradiotherapy: A Proof of Concept Study

Table 4

Summary of Mann–Whitney U test for taxonomic analysis of relative abundance of four main bacterial phyla.

Phylum	Fatigued	Nonfatigued	Mann–Whitney U
	Median	Median	U	value
Firmicutes/Bacteroidetes
Middle	0.74	0.32	50	0.08
End	0.22	1.33	79	0.07
Actinobacteria
Middle	0.002	0.002	78	0.76
End	0.0008	0.0009	61	0.57
Bacteroidetes
Middle	0.22	0.72	124	0.04
End	0.65	0.41	16	0.009
Firmicutes
Middle	0.23	0.23	71	0.51
End	0.14	0.51	78	0.08
Proteobacteria
Middle	0.13	0.05	61	0.24
End	0.09	0.23	54	0.94

and middle of treatment (fatigued n = 13; nonfatigued n = 13); end of treatment (fatigued n = 15; nonfatigued n = 7).