Calcium Carbonate versus Sevelamer Hydrochloride as Phosphate Binders after Long-Term Disease Progression in 5/6 Nephrectomized Rats

Table 1

Characteristics and laboratory findings in the study groups.

	Sham	Ca-Sham	Seve-Sham	NX	Ca-NX	Seve-NX
Weight of kidney tissue removed				6.3 ± 0.1	6.2 ± 0.1	6.2 ± 0.2
in the 5/6 nephrectomy (g/kg)
Body weight (g)
Week 15	454 ± 11	452 ± 8	452 ± 7	438 ± 7	447 ± 11	442 ± 16
Week 24	495 ± 13	474 ± 8	504 ± 12	476 ± 11	467 ± 16	459 ± 17
Systolic blood pressure (mmHg)
Week 15	125 ± 10	123 ± 9	118 ± 5	127 ± 6	133 ± 7	132 ± 5
Week 24	135 ± 4	136 ± 4	144 ± 7	169 ± 4*	151 ± 5^*†	167 ± 9*
Creatinine (mol/L)
Week 15	n.d.	n.d.	n.d.	88.2 ± 5.3	87.3 ± 7.1	88.6 ± 5.5
Week 24	49.6 ± 2.6	52.5 ± 1.9	53.2 ± 2.5	84.5 ± 7.6*	128.8 ± 25.7^*†	161.7 ± 33.2^*†
Sampling at close of the study (week 24)
pH	7.40 ± 0.05	7.43 ± 0.03	7.22 ± 0.07^*#	7.41 ± 0.03	7.34 ± 0.05	7.21 ± 0.04^*†
Sodium (mmol/L)	136.0 ± 0.5	135.7 ± 0.3	136.1 ± 0.5	136.7 ± 0.5	135.4 ± 0.6	138.2 ± 1.2
Potassium (mmol/L)	3.92 ± 0.09	3.79 ± 0.21	3.90 ± 0.07	4.49 ± 0.15*	4.88 ± 0.24*	5.12 ± 0.23^*†
Hemoglobin (g/L)	177.3 ± 2.1	175.0 ± 2.2	182.0 ± 1.3	158.3 ± 4.6*	157.3 ± 3.9*	143.9 ± 8.8^*†‡
Heart wt/body wt (g/kg)	3.48 ± 0.07	3.40 ± 0.06	3.92 ± 0.44	4.53 ± 0.48*	4.26 ± 0.23	5.45 ± 0.51^*‡
Ca-Pi product (mmol^2/L^2)	3.03 ± 0.14	2.05 ± 0.11*	3.22 ± 0.17^#	4.10 ± 0.49*	2.49 ± 0.26^*†	5.24 ± 0.53^*‡
Urine sampling at close of the study (week 24)
Protein (mg/24 h)	70.8 ± 8.0	74.2 ± 10.0	111.2 ± 26.8	242.3 ± 31.6*	260.5 ± 46.4*	285.2 ± 38.8*

Mean ± SEM; = 10–20 (see Figure 1); n.d. = not determined.
versus Sham, versus NX, Ca-NX versus Seve-NX, and Ca-Sham versus Seve-Sham.