Role of Calcium in Phosphatidylserine Externalisation in Red Blood Cells from Sickle Cell Patients

Figure 6

Effect of K⁺ and calmodulin inhibition on Ca²⁺-induced exposure of phosphatidylserine (PS) in red blood cells (RBCs) from sickle cell patients. Experimental details were as described in the legend to Figure 4, except that in (a) where incubation was carried out in either high K⁺-(HK, K⁺ = 90 mM) or low K⁺-containing saline (LK, 4 mM), and, in (b) where HK saline was used in the absence or presence of W-7 (100 𝜇M). Results are presented as single experiments representative of 3 others.

(a)

(b)