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Volume 2011 (2011), Article ID 698586, 7 pages
Clinical Study

Relationship between Painful Crisis and Serum Zinc Level in Children with Sickle Cell Anaemia

1Department of Paediatrics, College of Medicine, University of Lagos (CMUL), P.M.B 12003, Lagos, Nigeria
2Critical Rescue International (CRI), Plot 144, Oba Akran Road, Ikeja, Lagos, Nigeria
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine, Idi-Araba, University of Lagos, P.M.B. 12003, Lagos, Nigeria

Received 14 August 2010; Accepted 11 October 2010

Academic Editor: Duran Canatan

Copyright © 2011 Edamisan Olusoji Temiye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sickle cell anaemia (SCA) is associated with zinc deficiency; zinc supplementation may ameliorate some of its clinical manifestations including the relief of painful crisis. Subjects and Methods. Serum zinc levels were determined in 71 children with SCA and painful crisis and in equal numbers in steady state. Seventy-one children with AA genotype acted as controls. Qualitative assessment of zinc content of 24-hour dietary recall and the last meal consumed before blood was drawn was taken. Serum zinc was determined using atomic absorption spectrophotometer. Haemoglobin concentration and packed cell volume (PCV) were determined using standard methods. Results. The mean serum zinc concentration in the study was less than international reference range. The controls had significantly higher serum zinc concentrations than the SCA group ( versus μg/dL, ); this difference was due to the significantly lower values of serum zinc in SCA with painful crisis compared with the remaining two groups , . There was a positive correlation between serum zinc and haemoglobin concentration only in the control group ( ; ). Conclusion. The serum zinc levels in this study were low. Painful crisis in SCA may exert greater demand for zinc utilization in children with SCA thereby resulting in lower serum levels.