Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease
Mononuclear cell migration. Migration across a wound over 24 hours was significantly less in children with Hemoglobin SS than Controls. (a) shows a representative pair of Control and Hemoglobin SS wound migration assays. The freshly made wound was photographed at 0 (zero) hours, and the area migrated is measured after 24 hours. (b) shows the cumulative data for 8 Control and 5 Hemoglobin SS samples. The mean area migrated was less in children with Hemoglobin SS (28% versus 59% of the original wound area, ).