A DOG’s View of Fanconi Anemia: Insights from C. elegans

Figure 2

Protein schematic of FANCJ orthologs. C. elegans DOG-1, 983 aa, chicken FANCJ, 1252 aa and human, 1243 aa FANCJ proteins illustrating the position of the conserved DEAD Box (DEXDc) and helicase (HELICc) domains. The BRCA-1 interaction domain of human FANCJ is illustrated (BID). A full protein sequence alignment of DOG-1 and human FANCJ is shown in [8].