A DOG’s View of Fanconi Anemia: Insights from C. elegans
Figure 3
A model for DOG-1 function in genome stability and ICL response. The left panel illustrates DOG-1’s role in G-tract maintenance. G4 formation on the lagging strand is resolved by the helicase function of DOG-1 and replication proceeds efficiently. In the absence of DOG-1 HR mediated by the FA pathway resolves a subset of stalled forks. Repair utilizing the mutagenic NHEJ repair mechanism results in deletions. The right panel describes a possible model for DOG-1 ICL sensitivity. In the presence of DOG-1, G4 structures may be resolved and not available as substrate for ICL stabilization. In the absence of DOG-1 G4 structures are available as substrate for ICL stabilization leading to an in increase in fork stalling, which is interpreted as an ICL sensitivity phenotype.
