Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease
Figure 3
Preferential engraftment in sickle mice. (a) Peripheral WBC populations from normal mice engraft in homozygous sickle mice at a significantly () faster rate than control mice when transplanted without ablation but in the presence of costimulation blockade. The levels of WBC engraftment coincide with (b)–(d) corresponding correction of RBC, hemoglobin, and hematocrit in recipient mice.
