Fanconi Anemia Proteins and Their Interacting Partners: A Molecular Puzzle

Figure 1

Putative roles of FA proteins through their interacting partners. The involvement of FA proteins with their protein partners in the different molecular mechanisms that lead to regulation of transcription, cell cycle regulation, ROS detoxification, DNA repair, and cell survival. Loss of protein interactions between FA proteins and their partners through disease causing mutations in a FA gene could lead to a defective molecular function resulting in an array of phenotypes including BMF and congenital malformations.