FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors
Figure 1
Structures of FK228 analogues. (a) The parent compound FK228 was transformed into novel structural analogues by two isosteric substitutions. The modification of the trans-double bond and ester linkage in the native FK228 with two isosteric amide functional groups allows facile synthesis of analogues as well as retention of the same backbone structure. Various amino acids such as Val, Ala, Phe, 2-Nal, and Lys were introduced to investigate potency of the analogues. (b) Superimposed structures of FK228 (green) and a modified FK228 analogue (orange).
