Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease
Figure 2
Chronic and acute changes in vascular permeability in sickle mouse lungs. (a) Lung edema in middle-aged Berkeley sickle mice as determined by wet/dry weight ratios (). Control groups include young sickle mice () and young () and middle-aged () hemizygotes. (b) Vascular leakage in the indicated organs in Berkeley sickle mice intravenously injected with lysed red blood cells. Note that permeability is significantly increased by lysed red blood cells in the lung but not in other organs. **.
