Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia

<table>Schematic pathophysiology of hypogonadism and testicular infarction in sickle cell disease. The dashed arrow represents the blocking effect of gonadal failure over cyclic nucleotide-stimulated androgen production.</table>

Anemia

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Figure 1

Figure 1: Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia 