Review Article

Towards a Molecular Understanding of the Fanconi Anemia Core Complex

Figure 3

A model of CC interactions. (a) Models of the CC proteins that directly interact with one another, represented by black lines. Yeast and mammalian 2-hybrid and in vitro and translational studies have shown these interactions. (b) Associated CC interactions as shown by mammalian and yeast 3-hybrid experiments. (c) A model of how all the CC proteins interact to from the full CC, the requirement for the monoubiquitination event.
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(a) Direct interactions
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(b) Associated interactions
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(c) Model of the core complex