Beta-Thalassemia Major and Female Fertility: The Role of Iron and Iron-Induced Oxidative Stress

<table>Infertility in female patients with BTM seems to be originated mainly by the direct and the indirect effect of iron overload. The combined effect of iron deposition and increased OS (because of a significant prooxidants/antioxidants imbalance) results in the dysfunction of the female reproductive axis.</table>

Anemia

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Figure 1

Figure 1: Beta-Thalassemia Major and Female Fertility: The Role of Iron and Iron-Induced Oxidative Stress 