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Anemia
Volume 2016 (2016), Article ID 9310905, 8 pages
http://dx.doi.org/10.1155/2016/9310905
Review Article

Erythropoiesis in Malaria Infections and Factors Modifying the Erythropoietic Response

1Department of Haematogenetics, National Institute of Immunohaematology (ICMR), KEM Hospital, Parel, Mumbai 400012, India
2Surat Raktadan Kendra & Research Centre, Udhna Khatodara Urban Health Centre, Udhna Magdalla Road, Surat, Gujrat 395002, India

Received 19 October 2015; Accepted 2 February 2016

Academic Editor: Maria Stella Figueiredo

Copyright © 2016 Vrushali A. Pathak and Kanjaksha Ghosh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Anemia is the primary clinical manifestation of malarial infections and is responsible for the substantial rate of morbidity. The pathophysiology discussed till now catalogued several causes for malarial anemia among which ineffective erythropoiesis being remarkable one occurs silently in the bone marrow. A systematic literature search was performed and summarized information on erythropoietic response upon malaria infection and the factors responsible for the same. This review summarizes the clinical and experimental studies on patients, mouse models, and in vitro cell cultures reporting erythropoietic changes upon malaria infection as well as factors accountable for the same. Inadequate erythropoietic response during malaria infection may be the collective effect of various mediators generated by host immune response as well as parasite metabolites. The interplay between various modulators causing the pathophysiology needs to be explored further. Globin gene expression profiling upon malaria infection should also be looked into as abnormal production of globin chains could be a possible contributor to ineffective erythropoiesis.