Efficacy of Oral Acetaminophen and Intravenous Chlorpheniramine Maleate versus Placebo to Prevent Red Cell Transfusion Reactions in Children and Adolescent with Thalassemia: A Prospective, Randomized, Double-Blind Controlled Trial

Table 2

The associated risk between premedications and transfusion reactions.

	Active drugs	Placebo	p-value	OR	95%CI
	(N=73)	(N=74)
Fever 0 - 4 hrs
Yes	4(5.5)	6(8.1)	0.527	1.522	0.411-5.634
No	69(94.5)	68(91.9)
Fever 4 - 24 hrs
Yes	1(1.4)	1(1.4)	0.992	1.014	0.062-16.521
No	72(98.6)	73(98.6)
Rash 0 - 4 hrs
Yes	8(11)	7(9.5)	0.764	1.178	0.404-3.435
No	65(89)	67(90.5)
Rash 4 - 24 hrs
Yes	8(11)	19(25.7)	0.021	0.356	0.145-0.877
No	65(89)	55(74.3)

Note. Data were shown as number (%), and associated risks between treatment groups were analyzed by binary logistic regression; : p<0.05 is statistically significant.