Efficacy of Oral Acetaminophen and Intravenous Chlorpheniramine Maleate versus Placebo to Prevent Red Cell Transfusion Reactions in Children and Adolescent with Thalassemia: A Prospective, Randomized, Double-Blind Controlled Trial

Table 4

Risk factors for development of febrile reaction post RBC transfusion.

	Febrile reaction		p-value	Crude OR	95%CI
	Yes	No
	N = 12	N = 135
Thalassemia
ß thal/ß thal	3(15.8)	16(84.2)	0.166	5.250	0.503-54.777
ß thal/Hb E	8(8.1)	91(91.9)	0.405	2.462	0.295-20.540
Other	1(3.4)	28(96.6)		1
RBC products
LPRC	9(9.1)	90(90.9)	0.557	1.500	0.387-5.814
LDPRC	3(6.2)	45(93.8)		1
Age
	13.9±3.63	11.73±4.86	0.141	1.116	0.964-1.291
Gender
Male	7(8.5)	75(91.5)		1
Female	5(7.7)	60(92.3)	0.853	0.893	0.270-2.955
Premedications
Active drugs	5(6.8)	68(93.2)	0.565	0.704	0.213-2.328
Placebo	7(9.5)	67(90.5)		1

Note. Data were shown as number (%), mean±SD, and associated risks between treatment groups were analyzed by binary logistic regression; p<0.05 is statistically significant.
Abbreviations. ß thal/ß thal: homozygous beta thalassemia; ß thal/HbE: beta thalassemia/hemoglobin E; RBC: red blood cell; LPRC: leukocyte poor packed red cell; LDPRC: leukocyte depleted packed red cell