Research Article
The Trabecular Bone Score as a Predictor for Thalassemia-Induced Vertebral Fractures in Northeastern Thailand
Table 1
Baseline characteristics of 86 patients with thalassemia.
| | Characteristics | Transfusion-dependent thalassemia (TDT) (n = 57) | Non-transfusion-dependent thalassemia (NTDT) (n = 29) |
| | Mean age (min-max), years | 30.5 (18–60) | 35.5 (18–58) | | Mean pretransfused Hb (min-max), g/dL | 7.2 (4.9–8.8) | 7.6 (7.5–9.2) | | Mean serum ferritin (min-max), ng/mL | 2.690 (153–11,810) | 1.651 (336–7,869) | | Z-score BMD (min-max), g/cm2 | 0.7 (0.4–1.0) | 0.8 (0.5–1.0) | | TBS score (min-max) | 1.2 (0.8–1.5) | 1.3 (0.8–1.4) | | Gender, n (%) | | Female | 38 (66.6) | 14 (48.3) | | Male | 19 (33.4) | 15 (51.7) | | Splenectomy, n (%) | | No | 22 (38.6) | 25 (86.2) | | Yes | 35 (61.4) | 4 (13.8) | | Vertebral fractures, n (%) | | No | 48 (84.2) | 26 (89.6) | | Yes | 11 (15.8) | 3 (10.4) | | Low lumbar spine BMD, n (%) | | No | 30 (52.6) | 20 (68.9) | | Yes | 27 (47.4) | 9 (31.1) | | Low TBS, n (%) | | No | 53(93) | 26 (89.6) | | Yes | 4 (7) | 3 (10.4) | | Smoking, n (%) | | No | 51 (89.4) | 23 (79.3) | | Yes | 6 (10.6) | 6 (20.7) | | Menopause, n (%) | | No | 46 (80.7) | 25 (86.2) | | Yes | 11 (19.3) | 4 (13.8) | | Endocrinopathies, n (%) | | No | 44 (77.2) | 24 (82.7) | | Yes | 13 (22.8) | 5 (17.3) | | Phenotype group, n (%) | | β-thalassemia/Hb E | 52 (91.2) | 15 (51.7) | | Homozygous β-thalassemia | 3 (5.2) | 0 (0) | | Hb H disease | 0 (0) | 5 (17.2) | | Hb H disease with Hb CS | 0 (0) | 5 (17.2) | | EABart’s disease | 2 (3.6) | 4 (13.9) |
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Hb CS = hemoglobin constant spring; compound heterozygous Hb H and heterozygous Hb E. |
