Research Article
Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients
Table 1
Patient baseline characteristics for the total sample and stratified by serum ferritin level classification.
| | | Serum ferritin (ng/mL) | | <2500 (n = 22) | 2500–5000 (n = 20) | >5000 (n = 24) | Total (n = 66) | value |
| | Demographic | | | | | | | Age, years (mean ± SD) | 22.6 ± 8.9 | 22.6 ± 8.0 | 19.6 ± 3.7 | 21.5 ± 7.2 | 0.275 | | Sex, n (%) | | | | | 0.592 | | Male | 10 (45.5) | 6 (30.0) | 9 (37.5) | 25 (37.9) | | | Female | 12 (54.5) | 14 (70.0) | 15 (62.5) | 41 (62.1) | |
| | Clinical factors | | | | | | | Age of first transfusion, months (mean ± SD) | 109.2 ± 119.8 | 50.4 ± 61.5 | 23.2 ± 35.7 | 60.1 ± 86.8 | 0.003 | | Transfusion interval, weeks (mean ± SD) | 6.7 ± 10.3 | 6.0 ± 3.1 | 4.3 ± 1.9 | 5.6 ± 6.3 | 0.421 | | Type of chelation therapy, n (%) | | | | | | | Deferoxamine monotherapy | 1 (5.3) | 2 (11.1) | 1 (5.3) | 4 (7.1) | 0.261 | | Deferiprone monotherapy | 11 (57.9) | 7 (38.9) | 5 (26.3) | 23 (41.1) | | | Deferasirox monotherapy | 7 (36.8) | 7 (38.9) | 12 (63.2) | 26 (46.4) | | | Deferoxamine and deferasirox | 0 (0.0) | 2 (11.1) | 1 (5.3) | 3 (5.4) | | | Pre-transfusion Hb, g/dL (mean ± SD) | 6.9 ± 1.2 | 7.3 ± 1.4 | 7.4 ± 2.3 | 7.2 ± 1.7 | |
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Hb: hemoglobin, p < 0.01 compared with serum ferritin <2500. |
