Research Article
Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients
Table 4
Cardiac function stratified by presence of cardiac siderosis based on T2
MRI.
| | | None (T2 > 20 ms, n = 22) | Moderate (T2 10–15 ms, n = 2) | value |
| | Age, years (mean ± SD) | 20.9 ± 4.0 | 22.5 ± 2.1 | 0.247 | | Serum ferritin, ng/mL (mean ± SD) | 3732.9 ± 2096.8 | 9413.0 ± 5188.7 | 0.060 | | Cardiac T2 (ms) | 33.3 ± 9.2 | 11.2 ± 0.7 | 0.022 | | Echocardiography | | | | | LVPWDD (mm) | 8.7 ± 1.5 | 7.2 ± 0.0 | 0.059 | | LVSV (mL) | 64.7 ± 11.3 | 48.5 ± 6.4 | 0.067 | | LVEF (%) | 66.2 ± 4.7 | 60.0 ± 2.8 | 0.058 | | LVFS (%) | 36.5 ± 3.5 | 31.5 ± 2.1 | 0.050 | | LV diastolic function E/A ratio (m/s) | 1.7 ± 0.3 | 1.5 ± 0.4 | 0.531 | | LV diastolic function DT (ms) | 159.7 ± 43.3 | 165.0 ± 14.1 | 0.497 | | LV diastolic function E/E′ | 15.9 ± 21.3 | 12.2 ± 4.1 | 0.347 | | LV diastolic function IVRT (ms) | 64.7 ± 17.6 | 74.0 ± 0.0 | 0.348 | | LV diastolic function LAVI (mL/m2) | 29.3 ± 6.6 | 28.1 ± 3.0 | 0.870 | | Mean PA pressure, mmHg | 17.7 ± 8.5 | 27.0 ± 11.3 | 0.154 | | TAPSE, mm | 23.8 ± 3.6 | 17.0 ± 2.8 | 0.040 | | Electrocardiography, n (%) | | | 0.037 | | Normal | 12 (60.0) | 0 (0.0) | | | Tachycardia | 0 (0.0) | 1 (50.0) | | | T-wave inversion | 6 (30.0) | 0 (0.0) | | | Left ventricular hypertrophy | 0 (0.0) | 1 (50.0) | | | RBBB | 1 (5.0) | 0 (0.0) | | | Arrhythmia | 1 (5.0) | 0 (0.0) | |
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LVPWDD: left ventricular posterior wall diastolic diameter; LVPWSD: left ventricular posterior wall systolic diameter; LVEDV: left ventricular end-diastolic volume; LVESV: left ventricular end-systolic volume; LVSV: left ventricular stroke volume; LVEF: left ventricular ejection fraction; LVFS: left ventricular fractional shortening; LV: left ventricle; DT: deceleration time; IVRT: isovolumic (or isovolumetric) relaxation time; LAVI: left atrial volume index; PA: pulmonary artery; TAPSE: tricuspid annular plane systolic excursion; RBBB: right bundle branch block.
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