Anemia

Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies


Publishing date
15 Jun 2012
Status
Published
Submission deadline
16 Dec 2011

Lead Editor

1Hematology/Oncology Division, Department of Pediatrics, Georgia Health Sciences University, Augusta, GA 30907, USA

2Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA

3Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA


Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies

Description

Sickle cell disease (SCD) is the most common inherited disorder among individuals of African ancestry with an estimated 100 000 affected people in the United States. It is caused by an A to T point mutation in the beta globin gene that produces hemoglobin S, which polymerizes in the deoxygenated state, resulting in physical deformation or sickling of erythrocytes. Sickle erythrocytes promote vaso-occlusion and hemolysis, which are two major hallmarks of the disease. Rapid advances made in understanding the molecular genetics of SCD in the early part of the 20th century have not been matched by progress toward understanding its clinical complications and toward finding therapy. Recent advances in medicine have introduced new technologies to study SCD probing mechanisms underlying its complex pathogenesis. Research efforts have led to the development of animal models, successful therapies, and genomic approaches to characterize clinical subphenotypes toward improving patient care.

We invite authors to contribute original research and review articles reporting recent advances in SCD to stimulate further research and understanding of this monogenic disorder. Topics of special interest include mechanisms of gamma globin gene regulation, genetic modifiers of clinical phenotypes, mechanisms of hemolysis and new treatment strategies. We are particularly interested in articles describing genetic markers that define risk of developing clinical complications, metabolic markers for prediction of vaso-occlusion, new insights into the physiology of pain, and novel drug targets and therapies. Potential topics include, but are not limited to:

  • Recent developments in sickle cell disease research
  • Genetic modifiers of major clinical complications
  • Genetics of gamma globin gene regulation
  • Serum markers of vaso-occlusion
  • Endothelium dysfunction in the development of vaso-occlusive episodes
  • Mechanisms of pain in sickle cell disease and possible new therapeutic approaches
  • Role of hemolysis in endothelial dysfunction and vascular complications
  • Novel therapeutic agents in sickle cell disease
  • Latest technologies for clinical evaluation and measuring outcomes
  • Approach for diagnosis and treatment of silent stroke in sickle cell disease
  • Stem cell transplantation for sickle cell disease: advances and challenges
  • Gene therapy for sickle cell disease: where we are?

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ane/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 143594
  • - Editorial

Sickle Cell Disease: Genetics, Cellular and Molecular Mechanisms, and Therapies

Betty S. Pace | Solomon F. Ofori-Acquah | Kenneth R. Peterson
  • Special Issue
  • - Volume 2012
  • - Article ID 105349
  • - Research Article

Foetal Haemoglobin, Erythrocytes Containing Foetal Haemoglobin, and Hematological Features in Congolese Patients with Sickle Cell Anaemia

L. Tshilolo | V. Summa | ... | D. Labie
  • Special Issue
  • - Volume 2012
  • - Article ID 507894
  • - Research Article

Induction of Fetal Hemoglobin In Vivo Mediated by a Synthetic γ-Globin Zinc Finger Activator

Flávia C. Costa | Halyna Fedosyuk | ... | Kenneth R. Peterson
  • Special Issue
  • - Volume 2012
  • - Article ID 723520
  • - Review Article

Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia

Mário Angelo Claudino | Kleber Yotsumoto Fertrin
  • Special Issue
  • - Volume 2012
  • - Article ID 582018
  • - Research Article

Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease

Samit Ghosh | Fang Tan | Solomon F. Ofori-Acquah
  • Special Issue
  • - Volume 2012
  • - Article ID 387385
  • - Research Article

Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease

Elisabeth H. Javazon | Mohamed Radhi | ... | David R. Archer
  • Special Issue
  • - Volume 2012
  • - Article ID 492428
  • - Clinical Study

Integrating Interactive Web-Based Technology to Assess Adherence and Clinical Outcomes in Pediatric Sickle Cell Disease

Lori E. Crosby | Ilana Barach | ... | Monica J. Mitchell
  • Special Issue
  • - Volume 2012
  • - Article ID 156598
  • - Research Article

Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease

Solomon F. Ofori-Acquah | Iris D. Buchanan | ... | Beatrice E. Gee
  • Special Issue
  • - Volume 2012
  • - Article ID 428137
  • - Research Article

FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors

Levi Makala | Salvatore Di Maro | ... | Betty S. Pace
  • Special Issue
  • - Volume 2012
  • - Article ID 767501
  • - Research Article

Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

M. A. Emokpae | P. O. Uadia
Anemia
 Journal metrics
Acceptance rate13%
Submission to final decision81 days
Acceptance to publication15 days
CiteScore2.700
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