Irisin Regulates Hepatic Glucose Metabolism via AMPK and PI3K/Akt Activation

<div>Schematic diagram showing the roles of irisin in the regulation of glucose metabolism in the hepatopancreas of common carp. Irisin upregulated the expression of enzyme genes related to glycolysis (<i>gk</i>, <i>hk</i>, and <i>pfk</i>) and glycogen synthesis (<i>gs</i>) and downregulated the expression of enzyme genes related to glycogen phosphorylation (<i>gsk3b</i>) and gluconeogenesis (<i>fbpase</i>, <i>pepck</i>, and <i>g6pase</i>) via AMPK orPI3K/Akt. Finally, irisin caused the increase in hepatopancreas glycogen content.</div>

Aquaculture Nutrition

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Figure 10

Figure 10: Irisin Regulates Hepatic Glucose Metabolism via AMPK and PI3K/Akt Activation 