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Advances in Orthopedics
Volume 2014, Article ID 791539, 9 pages
http://dx.doi.org/10.1155/2014/791539
Research Article

A Longitudinal Low Dose μCT Analysis of Bone Healing in Mice: A Pilot Study

1Research Center of CHUS (CRCHUS), 3001, 12th Avenue North, Sherbrooke, QC, Canada J1H 5N4
2Department of Orthopedic Surgery, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, Canada J1H 5N4
3Sherbrooke Molecular Imaging Centre (CIMS), CRCHUS, 3001, 12th Avenue North, Sherbrooke, QC, Canada J1H 5N4
4Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001, 12th Avenue North, Sherbrooke, QC, Canada J1H 5N4
5Laboratoire d’Organogénèse Expérimentale (LOEX), Research Center of CHUQ, Enfant-Jésus Hospital, 1401, 18th Street, Quebec City, QC, Canada G1J 1Z4
6Department of Surgery, Faculty of Medicine, Laval University, 2325 Université Street, Quebec City, QC, Canada G1V 0A6
7Department of Chemical and Biotechnological Engineering, Faculty of Engineering, University of Sherbrooke, 2500 Université Boulevard, Sherbrooke, QC, Canada J1K 2R1

Received 11 June 2014; Accepted 13 October 2014; Published 6 November 2014

Academic Editor: Panagiotis Korovessis

Copyright © 2014 Lu-Zhao Di et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Bone healing kinetics assessment by three independent observers

Healing kinetics were plotted based on the 3D ROI determinations of three observers. The y-axis is the percentage of cortical defect volume compared to day 0, and the x-axis is time in post-operative days. The solid, dashed, and dotted lines represent the bone healing kinetics based on the 3D ROI determinations of three observers (A, B, and C). Filled and empty symbols represent the defect without reaming and the defect with reaming, respectively. (n=9)

  1. Supplementary Material