Advances in Orthopedics / 2015 / Article / Tab 2

Clinical Study

Long Term Anticoagulation (4–16 Years) Stops Progression of Idiopathic Hip Osteonecrosis Associated with Familial Thrombophilia

Table 2

Six patients, 9 hips (5 heterozygous for the V Leiden mutation, 1 with resistance to activated protein C). Anticoagulation for 4–16 years. Entry MRI and nonprogression by MRI.

PatientFollow-up (years)MRI finding at pretreatment entryProgression by follow-up MRI at end of study

Number 1 (2 hips) 4Osteonecrosis of right femoral head involving 25% of the superior articular surface
Small subcentimeter focus of low T1 and T2 signal intensity (sclerosis) in the left femoral head
None in both hips

Number 2 (right hip)4Subchondral osteonecrosis measures approximately 1 cm transversely by 2.2 cm in the AP dimension None in right hip

Number 3 (2 hips)9No subchondral collapse, serpiginous lesion with low signal intensity, confirming Ficat stage II by X-rayNo repeat MRI done

Number 4 (right hip)13Osteonecrosis of right femoral head involving 20% of the superior articular surfaceNone in right hip

Number 5 (2 hips)13Osteonecrosis of right femoral head involving 30% of the superior articular surface
Osteonecrosis of left femoral head involving 30% of the superior articular surface
None in both hips

Number 6 (right hip)16Osteonecrosis of right femoral head involving 30% of superior articular surfaceNone in right hip