Advances in Orthopedics / 2020 / Article / Tab 1 / Clinical Study
Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study Table 1 Demographic and disease history at baseline and during follow-up of the study.
Demographics Baseline 6–11 Mo 12–35 Mo 36–48 Mo 49–60 Mo (n = 309) (n = 309) (n = 255) (n = 206) (n = 48) Gender Female; n (%) 208 (67) Male; n (%) 101 (33) Age (years); mean ± SD 64.0 ± 8.7 (Range) (45–82) Body mass index (kg/m2 ); mean ± SD; 23.9 ± 3.2 (Range) (18.2–34.6) Kellgren-Lawrence grade II; n (%) 160 (52) III; n (%) 149 (48) Deformity Valgus; n (%) 7 (2) Varus; n (%) 302 (98) Clinical variables WOMAC pain subscale; mean ± SD 6.1 ± 3.4 4.4 ± 3.1 3.4 ± 2.4 4.3 ± 2.2 3.6 ± 2.1 (Range) (2–16) (0–14) (0–14) (2–10) (2–12) Δ (%) −27.8 −44.2 −29.5 −41.0 WOMAC stiffness subscale; mean ± SD 4.2 ± 2.0 3.2 ± 1.7 2.5 ± 1.5 2.8 ± 1.5 2.4 ± 1.1 (Range) (2–10) (1–10) (0–12) (2–8) (0–6) Δ (%) −23.8 −40.47 −33.3 −42.9 WOMAC disability; mean ± SD 21.0 ± 4.9 19.1 ± 4.8 16.3 ± 4.9 17.2 ± 5.4 15.9 ± 5.5 (Range) (2–36) (10–32) (2–30) (6–32) (4–32) Δ (%) −9.0 −22.4 −18.1 −24.3 Patient pain (mm); mean ± SD 56.2 ± 13.5 32.1 ± 15 35.5 ± 13.6 29.4 ± 11.7 20.4 ± 10.6 (Range) (30–100) (0–80) (20–70) (0–70) (0–60) Δ (%) −42.9 −36.8 −47.7 −63.7 Physician pain (mm); mean ± SD 54.0 ± 12.6 29.7 ± 13.2 30.4 ± 13.9 25.1 ± 12.1 20.1 ± 10.6 (Range) (30–100) (0–80) (20–70) (0–70) (0–60) Δ (%) −45.0 −43.7 −53.5 −62.8 Patient Likert score (cm); mean ± SD 1.8 ± 0.9 2.1 ± 1.0 2.3 ± 0.9 2.5 ± 0.8 2.9 ± 0.7 (Range) (0–3) (0–8) (0–6) (0–6) (1–6) Δ (%) 18.3 27.8 38.9 61.1 Physician Likert score (cm); mean ± SD 1.8 ± 1.0 2.2 ± 1.0 2.3 ± 0.9 2.6 ± 0.9 3.0 ± 0.7 (Range) (0–6) (0–6) (0–6) (0–6) (1–6) Δ (%) 22.0 27.8 44.4 66.7 Patient drug evaluation (cm); mean ± SD 2.4 ± 0.9 2.0 ± 0.9 2.2 ±0.7 3.1 ± 0.5 (Range) (0–4) (0–4) (1–4) (2–4) Δ (%) 6.0 9.1 29.2 Physician drug evaluation (cm); mean ± SD 2.1 ± 1.0 1.9 ± 0.9 2.1 ± 0.9 2.8 ± 0.7 (Range) (0–4) (0–3) (0–4) (1–4) Δ (%) 8.0 0.0 33.3
Bold numbers depict clinically significant improvement.