Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study
Table 3
Extended Cox model of relapse-free survival during the follow-up period including time-varying covariates.
Characteristic
Adjusted HR (95% CI)
value
Fixed effects
Age (years)
0.9190 (0.8850, 0.9530)
<0.0001
Females (ref.) vs. males
2.3790 (1.2510, 4.5220)
0.0008
Baseline BMI (kg/m2)
Underweight
0.0000 (0.0000, 0.0000)
0.9872
Normal weight
Ref.
–
Overweight
2.3560 (1.1740, 4.7270)
0.0159
Obese
3.4610 (1.4620, 8.1900)
0.0047
Arthrosis grade
II
Ref.
III
2.6460 (1.3230, 5.2900)
0.0059
Baseline clinical scores (U)
WOMAC
1.0500 (1.0010, 1.1020)
0.0442
100 mm VAS-MD
0.8790 (0.5850, 1.3190)
0.5327
100 mm VAS-PT
1.1080 (0.7480, 1.6410)
0.6090
Time covarying effects
WOMAC
0.9990 (1.9980, 1.0010)
0.5449
100 mm VAS-MD
—
—
100 mm VAS-PT
—
—
“—” means model did not converge. Significant predictors at the 0.05 level are displayed in bold, and those at the 0.10 level (marginally significant) are displayed in italics.
