Review Article
Prophylactic Topical Antibiotics in Fracture Repair and Spinal Fusion
Table 2
Summary of infection rates and methodology of studies of fracture repair.
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Abbreviations: No., number; pts, patients; RCT, randomized controlled trial; PC, prospective cohort; RC, retrospective cohort; NR, not reported; DBM, demineralized bone matrix; PMMA, polymethyl methacrylate. aWe combined the two treatment groups into one intervention group in our analysis. bThe treatment group received just antibiotic beads, and the control group received just parenteral antibiotics. Not included are the nonrandomized third cohort that received antibiotic beads + IV. This group of patients all had Grade 3 Gustilo–Anderson open fractures. cWe included only deep SSI, which was the primary study outcome. Superficial SSI was excluded because the sample sizes for superficial SSI did not match those for deep SSI. dThis study conducted analyses using two separate methods of matching: nearest-neighbor matching and propensity score matching. It also had both prospective and retrospective control cohorts. We included the data from propensity scores matching with the prospective control cohort. ‡Only deep infections were reported in this study. Studies showed a significant difference between the control and treatment groups. |