The Comparison of Inflammatory Cytokines between Spinal and General Anesthesia following Changes in Ischemic Reperfusion due to Tourniquet during Lower Limb Surgery

Table 1

The pattern of changes of inflammatory cytokines during the study period and between groups.

	General anesthesia			Spinal anesthesia			value	value^+
	Before	12 hours later	24 hours later	Before	12 hours later	24 hours later
hs-CRP	3132.29 ± 2318.46	4404.53 ± 2102.69	4225.82 ± 2187.66	4822.94 ± 1393.18	5345.41 ± 603.76	5673.65 ± 431.05	<0.001	0.28
IL-6	14.03 ± 24.42	64.01 ± 79.47	37.04 ± 55.09	18.57 ± 29.09	56.28 ± 42.99	31.80 ± 24.18	<0.001	0.58
TNF-α	7.42 ± 2.88	33.15 ± 89	8.10 ± 3.53	9.02 ± 1.10	8.61 ± 2.38	6.54 ± 1.80	0.23	0.25
FER	74.29 ± 49.29	82.72 ± 44.74	78.66 ± 33.12	158.94 ± 177.77	138.51 ± 106.81	116.02 ± 85.19	0.14	0.07

value for the main effect. ⁺ value for the interaction effect. Mauchly’s W for hs-CRP ( value) = 0.92 (0.30). Mauchly’s W for IL-6 ( value) = 0.43 (<0.001). Mauchly’s W for TNF-α ( value) = 0.004 (<0.001). Mauchly’s W for FER ( value) = 0.17 (<0.001). Significance of the bold value is < 0.05.