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Advances in Preventive Medicine
Volume 2012 (2012), Article ID 149737, 4 pages
The Need for Continued Development of Ricin Countermeasures
1Division of Clinical Medicine, Clinical Research Management Inc., Team Ke’aki Tech, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA
2Division of Toxinology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702-5011, USA
Received 1 August 2011; Accepted 10 January 2012
Academic Editor: Phillip R. Pittman
Copyright © 2012 Ronald B. Reisler and Leonard A. Smith. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citations to this Article [23 citations]
The following is the list of published articles that have cited the current article.
- Joanne M. O'Hara, and Nicholas J. Mantis, “Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro,” Journal of Immunological Methods, vol. 395, no. 1-2, pp. 71–78, 2013.
- Erin E. Endom, “Bioterrorism and the pediatric patient: An update,” Clinical Pediatric Emergency Medicine, vol. 14, no. 2, pp. 102–117, 2013.
- Joanne M. O'Hara, Robert N. Brey, and Nicholas J. Mantis, “Comparative Efficacy of Two Leading Candidate Ricin Toxin A Subunit Vaccines in Mice,” Clinical And Vaccine Immunology, vol. 20, no. 6, pp. 789–794, 2013.
- Laszlo Janosi, Jaimee R. Compton, Patricia M. Legler, Keith E. Steele, Jon M. Davis, Gary R. Matyas, and Charles B. Millard, “Disruption of the Putative Vascular Leak Peptide Sequence in the Stabilized Ricin Vaccine Candidate RTA1-33/44-198,” Toxins, vol. 5, no. 2, pp. 224–248, 2013.
- David J. Vance, Jacqueline M. Tremblay, Nicholas J. Mantis, and Charles B. Shoemaker, “Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin,” Journal of Biological Chemistry, vol. 288, no. 51, pp. 36538–36547, 2013.
- Alex Skvortsov, and Peter Gray, “A Simple Model for Assessment of Anti-Toxin Antibodies,” BioMed Research International, vol. 2013, pp. 1–8, 2013.
- Cristina Herrera, David J. Vance, Leslie E. Eisele, Charles B. Shoemaker, and Nicholas J. Mantis, “Differential Neutralizing Activities of a Single Domain Camelid Antibody (VHH) Specific for Ricin Toxin's Binding Subunit (RTB),” Plos One, vol. 9, no. 6, 2014.
- Michael J. Rudolph, David J. Vance, Jonah Cheung, Matthew C. Franklin, Fiana Burshteyn, Michael S. Cassidy, Ebony N. Gary, Cristina Herrera, Charles B. Shoemaker, and Nicholas J. Mantis, “Crystal Structures of Ricin Toxin’s Enzymatic Subunit (RTA) in Complex with Neutralizing and Non-neutralizing Single Chain Antibodies,” Journal of Molecular Biology, 2014.
- Michelle Cummins, Con Dogovski, Remy Robert, Malcolm Alderton, Damien Chong, David Proll, Luisa Pontes-Braz, Anna Raicevic, Meghan Hattarki, Stewart Nuttall, and Olan Dolezal, “Kinetic Characterization of a Panel of High-Affinity Monoclonal Antibodies Targeting Ricin and Recombinant Re-Formatting for Biosensor Applications,” Antibodies, vol. 3, no. 2, pp. 215–231, 2014.
- Vladas Skakauskas, Pranas Katauskis, and Peter Gray, “Modelling effects of internalized antibody: a simple comparative study,” Theoretical Biology and Medical Modelling, vol. 11, 2014.
- David J. Vance, Yinghui Rong, Robert N. Brey, and Nicholas J. Mantis, “Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice,” Vaccine, 2014.
- Kirsten Sandvig, Jonas Bergan, Simona Kavaliauskiene, and Tore Skotland, “Lipid requirements for entry of protein toxins into cells,” Progress in Lipid Research, 2014.
- Nayanna Brunna da Silva Fonseca, and Benito Soto-Blanco, “Toxicity of ricin present in castor bean seeds,” Semina-Ciencias Agrarias, vol. 35, no. 3, pp. 1415–1424, 2014.
- Vladas Skakauskas, and Pranas Katauskis, “Modeling of toxin–antibody interaction and toxin transport toward the endoplasmic reticulum,” Journal of Biological Physics, 2015.
- Seth H. Pincus, Manoj Bhaskaran, Robert N. Brey, Peter J. Didier, Lara A. Doyle-Meyers, and Chad J. Roy, “Clinical and Pathological Findings Associated with Aerosol Exposure of Macaques to Ricin Toxin,” Toxins, vol. 7, no. 6, pp. 2121–2133, 2015.
- Cristina Herrera, Jacqueline M. Tremblay, Charles B. Shoemaker, and Nicholas J. Mantis, “Mechanisms of Ricin Toxin Neutralization Revealed through Engineered Homodimeric and Heterodimeric Camelid Antibodies,” Journal Of Biological Chemistry, vol. 290, no. 46, pp. 27880–+, 2015.
- Vladas Skakauskas, Pranas Katauskis, Alex Skvortsov, and Peter Gray, “Toxin effect on protein biosynthesis in eukaryotic cells: a simple kinetic model,” Mathematical Biosciences, 2015.
- Kendrick B. Turner, Jinny L. Liu, Dan Zabetakis, Audrey Brozozog Lee, George P. Anderson, and Ellen R. Goldman, “Improving the biophysical properties of anti-ricin single-domain antibodies,” Biotechnology Reports, 2015.
- Amanda E. Jetzt, Xiao-Ping Li, Nilgun E. Tumer, and Wendie S. Cohick, “Toxicity of ricin A chain is reduced in mammalian cells by inhibiting its interaction with the ribosome,” Toxicology and Applied Pharmacology, 2016.
- Renaud Respaud, Denis Marchand, Thibaut Pelat, Kam-Meng Tchou-Wong, Chad J. Roy, Christelle Parent, Maria Cabrera, Joël Guillemain, Ronan Mac Loughlin, Eric Levacher, Alexandre Fontayne, Laurence Douziech-Eyrolles, Alexandra Junqua-Moullet, Laurent Guilleminault, Philippe Thullier, Emmanuelle Guillot-Combe, Laurent Vecellio, and Nathalie Heuzé-Vourc'h, “Development of a drug delivery system for efficient alveolar delivery of a neutralizing monoclonal antibody to treat pulmonary intoxication to ricin,” Journal of Controlled Release, 2016.
- Paul D.R. Dyer, Arun K. Kotha, Alex S. Gollings, Susan A. Shorter, Thomas R. Shepherd, Marie W. Pettit, Bruce D. Alexander, Giulia T.M. Getti, Samer El-Daher, Les Baillie, and Simon C.W. Richardson, “An in vitro evaluation of epigallocatechin gallate (eGCG) as a biocompatible inhibitor of ricin toxin,” Biochimica et Biophysica Acta (BBA) - General Subjects, 2016.
- Newton Wahome, Erin Sully, Christopher Singer, Justin C. Thomas, Lei Hu, Sangeeta B. Joshi, David B. Volkin, Jianwen Fang, John Karanicolas, Donald J. Jacobs, Nicholas J. Mantis, and C. Russell Middaugh, “Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice,” Journal of Pharmaceutical Sciences, 2016.
- Berta Esteban-Fernández de Ávila, Miguel Angel Lopez Ramirez, Daniela F. Báez, Adrian Jodra, Virendra V Singh, Kevin Kaufmann, and Joseph Wang, “Aptamer-Modified Graphene-Based Catalytic Micromotors: Off-On Fluorescent Detection of Ricin.,” ACS Sensors, 2016.