Advances in Preventive Medicine / 2012 / Article / Tab 3

Review Article

Advanced Development of the rF1V and rBV A/B Vaccines: Progress and Challenges

Table 3

Clinical signs, gross pathology and histopathology associated with plague infection1.

Symptom or lesionHumanHistorical CMDVC SW mouseDVC CM

LymphadenopathyYesYesYesYes
FeverYesYesNDYes
MalaiseYesYesYesYes
LethargyYesYesYesYes
Elevated pulseYesYesNDYes
CyanosisYes (late)YesNDND
PharyngitisYesYesNDND
CoughYesNDNDYes
RalesYesYesNDND
SepsisYesYesYesYes

Gross pathology primary pneumonic plague
Fibrinous pleuritisYesNDNDYes
PneumoniaYesYesYesYes
Mediastinal hemorrhageYesYesNDYes
Congestion of trachea/bronchiYesYesYesYes

Histopathology primary pneumonic plague
Pulmonary congestionYesYesYesYes
Necrohemorrhagic fociYesYesYesYes
Fibrinous pleuritisYesYesNDYes
Disseminated intravascular coagulationYesYesNDND
Neutrophil infiltration of lungYesYesYesYes
Bacteria in lungYesYesYesYes
MediastinitisYesYesYesYes
Bacteria in spleenYesYesYesYes2

1 Modified from information contained in Adamovicz and Worsham [16].
CM: cynomolgus macaque, ND: not determined, SW: Swiss Webster.
2Bacterial burden not quantitated.

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