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Advances in Preventive Medicine
Volume 2016, Article ID 1407840, 9 pages
Research Article

Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation

1Departments of Surgery, Jefferson Pancreatic, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
2Department of Biomedical Sciences, University of New England, Biddeford, ME, USA

Received 23 March 2016; Revised 29 August 2016; Accepted 23 November 2016

Academic Editor: William C. Cho

Copyright © 2016 Daniel Relles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

The following is the list of published articles that have cited the current article.

  • Inki Kim, Yeon-Sook Choi, Jae Hwi Song, Eun A Choi, Sojung Park, Eun Ji Lee, Je-Keun Rhee, Song Cheol Kim, and Suhwan Chang, “A drug-repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6-thioguanine as an effective therapeutic agent for TPMT-low cancer cells,” Molecular Oncology, 2018. View at Publisher · View at Google Scholar
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  • Md. Asaduzzaman Khan, Mousumi Tania, and Junjiang Fu, “Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics,” Drug Discovery Today, 2019. View at Publisher · View at Google Scholar
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  • Shahad A Qadi, Mohammed A Hassan, Ryan A Sheikh, Othman AS Baothman, Mazin A Zamzami, Hani Choudhry, Abdulrahman Labeed Al-Malki, Ashwag Albukhari, and Mahmoud Alhosin, “Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms,” Epigenetics Insights, vol. 12, pp. 251686571983901, 2019. View at Publisher · View at Google Scholar
  • Sabrina Bimonte, Vittorio Albino, Antonio Barbieri, Maria Luisa Tamma, Aurelio Nasto, Raffaele Palaia, Carlo Molino, Paolo Bianco, Andrea Vitale, Rita Schiano, Aldo Giudice, and Marco Cascella, “Dissecting the roles of thymoquinone on the prevention and the treatment of hepatocellular carcinoma: an overview on the current state of knowledge,” Infectious Agents and Cancer, vol. 14, no. 1, 2019. View at Publisher · View at Google Scholar
  • K. I. Kirsanov, O. A. Vlasova, T. I. Fetisov, R. G. Zenkov, E. A. Lesovaya, G. A. Belitsky, K. Gurova, and M. G. Yakubovskaya, “Influence of DNA-binding compounds with cancer preventive activity on the mechanisms of gene expression regulation,” Advances in molecular oncology, vol. 5, no. 4, pp. 41–63, 2019. View at Publisher · View at Google Scholar