Advances in Preventive Medicine / 2020 / Article / Tab 4

Research Article

Assessment of Prescriptions in the Endocrinology Department of a Tertiary Care Hospital in Pakistan Using World Health Organization Guidelines

Table 4

Drug-drug interactions.

Degree of interactionInteracting combinationFrequency (%)Consequences

MinorAspirin + frusemide4 (3.6)Combination effect level of potassium in serum affects CYP3A4 enzyme in liver antagonize hypoglycemic effect
Dexamethasone + omeprazole2 (1.8)
Insulin + frusemide6 (5.5)
ModerateGlimepiride + aspirin1 (0.9)Hypoglycemia chances
Dexamethasone + aspirin1 (0.9)Peptic ulceration chances
Dexamethasone + clopidogrel1 (0.9)Affects CYP3A4 enzyme in the liver
Dexamethasone + insulin1 (0.9)Antagonize hypoglycemic effect
MajorMetformin + metformin1 (0.9)Severe hypoglycemia chances
Heparin + aspirin + toradol1 (0.9)Bleeding chances
Dexamethasone + hydrocortisone1 (0.9)Steroid toxicity chances (cushing syndrome)
Dexamethasone + triamcinolone1 (0.9)
Total20 (18.1)

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