Clinical and Histopathological Factors Associated with the Tumoral Expression of TGF-β1, MED15, CD16, and CD57 in Oral Squamous Cell Carcinoma

Table 1

The correlation matrix among variables, calculated using the Spearman coefficient.

		Sex: male	Age	Tumor size	Tumor volume	Tumor depth	Grade	Necrosis	Lymph invasion	Vascular invasion	Perineural invasion	Nodal extension	Stage	Smoking
Sex: male	Rho		−0.035	0.165	−0.013	−0.112	0.109	0.216	0.110	−0.040	0.025	0.038	0.182	0.334
			0.811	0.266	0.932	0.459	0.466	0.144	0.460	0.790	0.869	0.801	0.220	0.020
Age at diagnosis	Rho	−0.035		0.166	0.147	0.062	−0.249	−0.023	0.157	0.215	0.123	−0.212	−0.038	−0.019
		0.811		0.266	0.325	0.681	0.092	0.878	0.292	0.146	0.412	0.153	0.799	0.897
Tumor size (mm)	Rho	0.165	0.166		0.775	0.359	−0.014	0.123	0.376	0.200	0.311	−0.042	0.349	−0.111
		0.266	0.266		<0.001	0.014	0.928	0.409	0.009	0.177	0.033	0.780	0.016	0.459
Tumor volume (ml)	Rho	−0.013	0.147	0.775		0.653	−0.170	0.077	0.173	0.116	0.387	−0.083	0.305	−0.234
		0.932	0.325	<0.001		<0.001	0.252	0.608	0.246	0.439	0.007	0.577	0.037	0.114
Depth of invasion (mm)	Rho	−0.112	0.062	0.359	0.653		0.033	0.110	0.155	0.114	0.224	0.028	0.091	−0.167
		0.459	0.681	0.014	<0.001		0.826	0.467	0.302	0.451	0.134	0.852	0.546	0.267
Histology grade	Rho	0.109	−0.249	−0.014	−0.170	0.033		0.108	0.108	0.012	−0.110	0.348	0.336	0.109
		0.466	0.092	0.928	0.252	0.826		0.468	0.468	0.939	0.462	0.016	0.021	0.464
Necrosis presence	Rho	0.216	−0.023	0.123	0.077	0.110	0.108		0.238	0.011	−0.089	0.077	−0.119	0.075
		0.144	0.878	0.409	0.608	0.467	0.468		0.107	0.940	0.553	0.607	0.426	0.618
Lymphatic invasion	Rho	0.110	0.157	0.376	0.173	0.155	0.108	0.238		0.672	0.125	0.077	0.053	−0.217
		0.460	0.292	0.009	0.246	0.302	0.468	0.107		<0.001	0.402	0.607	0.723	0.142
Vascular invasion	Rho	−0.040	0.215	0.200	0.116	0.114	0.012	0.011	0.672		0.284	−0.127	0.090	−0.052
		0.790	0.146	0.177	0.439	0.451	0.939	0.940	<0.001		0.053	0.395	0.545	0.730
Perineural invasion	Rho	0.025	0.123	0.311	0.387	0.224	−0.110	−0.089	0.125	0.284		−0.027	0.164	−0.084
		0.869	0.412	0.033	0.007	0.134	0.462	0.553	0.402	0.053		0.859	0.270	0.576
Extracapsular nodal extension	Rho	0.038	−0.212	−0.042	−0.083	0.028	0.348	0.077	0.077	−0.127	−0.027		0.224	−0.109
		0.801	0.153	0.780	0.577	0.852	0.016	0.607	0.607	0.395	0.859		0.130	0.465
Stage	Rho	0.182	−0.038	0.349	0.305	0.091	0.336	−0.119	0.053	0.090	0.164	0.224		−0.151
		0.220	0.799	0.016	0.037	0.546	0.021	0.426	0.723	0.545	0.270	0.130		0.310
Smoking	Rho	0.334	−0.019	−0.111	−0.234	−0.167	0.109	0.075	−0.217	−0.052	−0.084	−0.109	−0.151
		0.020	0.897	0.459	0.114	0.267	0.464	0.618	0.142	0.730	0.576	0.465	0.310
ΔΔCt CD16 (log2-fold-change)	Rho	0.192	−0.250	−0.179	−0.013	0.053	0.133	0.119	−0.199	−0.255	−0.207	0.077	−0.169	0.322
		0.191	0.087	0.229	0.933	0.728	0.373	0.426	0.179	0.083	0.164	0.607	0.256	0.026
ΔΔCt CD57 (log2-fold-change)	Rho	0.469	−0.222	−0.206	−0.175	−0.105	0.110	0.103	−0.276	−0.271	−0.216	0.000	−0.030	0.475
		0.001	0.129	0.164	0.240	0.487	0.464	0.489	0.060	0.065	0.144	1.000	0.839	0.001
ΔΔCt TGF-β1 (log2-fold-change)	Rho	0.151	−0.090	−0.207	−0.063	0.048	0.156	0.073	−0.230	−0.146	−0.181	0.010	−0.009	0.409
		0.307	0.543	0.164	0.674	0.751	0.294	0.627	0.120	0.329	0.224	0.949	0.954	0.004
ΔΔCt MED15 (log2-fold-change)	Rho	0.029	−0.164	−0.031	0.004	0.026	0.015	0.084	−0.069	−0.191	−0.365	−0.038	−0.075	0.254
		0.844	0.266	0.838	0.979	0.865	0.923	0.573	0.645	0.198	0.012	0.797	0.614	0.082