Clinical and Histopathological Factors Associated with the Tumoral Expression of TGF-β1, MED15, CD16, and CD57 in Oral Squamous Cell Carcinoma

Table 3

Factors associated with the ΔΔCt CD57, calculated using the backward-selection stepwise log-level multiple linear regression.

Models and parameters		Unstandardized coefficients		Beta		95% CI		VIF
		B	SE			Low	Up
1	(Constant)	0.344	2.829		0.904	−5.405	6.094
	Sex: male	2.772	1.116	0.364	0.018	0.505	5.040	1.456
	Age at diagnosis	−0.042	0.033	−0.171	0.206	−0.108	0.024	1.198
	Tumor size (mm)	−0.021	0.024	−0.143	0.384	−0.069	0.027	1.785
	Depth of invasion (mm)	0.029	0.038	0.117	0.447	−0.048	0.107	1.573
	Histology grade	−0.308	0.853	−0.051	0.720	−2.041	1.425	1.340
	Necrosis presence	0.080	1.208	0.009	0.947	−2.375	2.536	1.196
	Vascular invasion	−1.622	1.249	−0.171	0.203	−4.161	0.917	1.182
	Perineural invasion	−0.770	1.053	−0.100	0.470	−2.910	1.370	1.282
	Extracapsular nodal extension	0.056	2.111	0.004	0.979	−4.234	4.346	1.303
	Stage	0.226	0.584	0.059	0.702	−0.962	1.414	1.598
	Smoking	4.317	1.437	0.409	0.005	1.396	7.237	1.258
7	(Constant)	0.544	2.004		0.787	−3.506	4.595
	Sex: male	2.669	0.925	0.350	0.006	0.799	4.539	1.133
	Age at diagnosis	−0.041	0.029	−0.166	0.169	−0.099	0.018	1.072
	Tumor size (mm)	−0.013	0.017	−0.088	0.452	−0.047	0.021	1.038
	Vascular invasion	−1.811	1.120	−0.191	0.114	−4.075	0.453	1.075
	Smoking	4.185	1.288	0.396	0.002	1.583	6.788	1.143
8	(Constant)	0.098	1.906		0.959	−3.752	3.947
	Sex: male	2.618	0.918	0.343	0.007	0.764	4.472	1.127
	Age at diagnosis	−0.043	0.029	−0.174	0.145	−0.101	0.015	1.063
	Vascular invasion	−1.892	1.109	−0.200	0.096	−4.132	0.348	1.066
	Smoking	4.293	1.273	0.407	0.002	1.722	6.865	1.129
9	(Constant)	−2.532	0.719		0.001	−3.983	−1.080
	Sex: male	2.601	0.931	0.341	0.008	0.723	4.480	1.127
	Vascular invasion	−2.291	1.092	−0.242	0.042	−4.494	−0.088	1.003
	Smoking	4.232	1.291	0.401	0.002	1.627	6.837	1.128

B, regression coefficient; SE, standard error; beta, standard regression coefficient; CI, confidence interval; VIF, variance inflation factor.