Clinical and Histopathological Factors Associated with the Tumoral Expression of TGF-β1, MED15, CD16, and CD57 in Oral Squamous Cell Carcinoma

Table 4

Factors associated with the ΔΔCt TGF-β1, computed using the backward-selection stepwise log-level multiple linear regression.

Models and parameters		Unstandardized coefficients		Beta		95% CI		VIF
		B	SE			Low	Up
1	(Constant)	0.902	3.450		0.795	−6.109	7.912
	Sex: male	0.123	1.361	0.015	0.928	−2.642	2.889	1.456
	Age at diagnosis	−0.045	0.040	−0.168	0.263	−0.126	0.036	1.198
	Tumor size (mm)	−0.056	0.029	−0.348	0.062	−0.114	0.003	1.785
	Depth of invasion (mm)	0.075	0.047	0.271	0.118	−0.020	0.170	1.573
	Histology grade	0.043	1.040	0.006	0.967	−2.070	2.156	1.340
	Necrosis presence	0.878	1.473	0.088	0.555	−2.116	3.871	1.196
	Vascular invasion	−1.269	1.523	−0.122	0.411	−4.365	1.827	1.182
	Perineural invasion	−1.046	1.284	−0.124	0.421	−3.656	1.563	1.282
	Extracapsular nodal extension	−1.620	2.574	−0.097	0.533	−6.851	3.611	1.303
	Stage	0.883	0.713	0.211	0.224	−0.565	2.331	1.598
	Smoking	5.231	1.752	0.451	0.005	1.670	8.792	1.258
7	(Constant)	3.125	2.419		0.204	−1.763	8.013
	Age at diagnosis	−0.045	0.035	−0.167	0.210	−0.116	0.026	1.031
	Tumor size (mm)	−0.040	0.026	−0.252	0.123	−0.092	0.011	1.538
	Depth of invasion (mm)	0.074	0.043	0.269	0.090	−0.012	0.161	1.435
	Perineural invasion	−1.315	1.170	−0.156	0.268	−3.680	1.051	1.164
	Smoking	5.218	1.513	0.450	0.001	2.161	8.274	1.024
8	(Constant)	3.325	2.420		0.177	−1.562	8.212
	Age at diagnosis	−0.050	0.035	−0.185	0.162	−0.121	0.021	1.015
	Tumor size (mm)	−0.048	0.025	−0.299	0.061	−0.098	0.002	1.434
	Depth of invasion (mm)	0.072	0.043	0.260	0.101	−0.015	0.158	1.432
	Smoking	5.310	1.515	0.458	0.001	2.250	8.370	1.021
9	(Constant)	0.310	1.181		0.795	−2.074	2.693
	Tumor size (mm)	−0.052	0.025	−0.322	0.045	−0.102	−0.001	1.417
	Depth of invasion (mm)	0.073	0.043	0.263	0.101	−0.015	0.160	1.431
	Smoking	5.235	1.533	0.452	0.001	2.142	8.328	1.019

B, regression coefficient; SE, standard error; beta, standard regression coefficient; CI, confidence interval; VIF, variance inflation factor.