Clinical and Histopathological Factors Associated with the Tumoral Expression of TGF-β1, MED15, CD16, and CD57 in Oral Squamous Cell Carcinoma

Table 5

Factors associated with the ΔΔCt MED15, calculated using the backward-selection stepwise log-level multiple linear regression.

Models and parameters		Unstandardized coefficients		Beta		95% CI		VIF
		B	SE			Low	Up
1	(Constant)	2.384	3.044		0.439	−3.801	8.570
	Sex: male	−0.455	1.200	−0.066	0.707	−2.895	1.984	1.456
	Age at diagnosis	−0.036	0.035	−0.163	0.307	−0.108	0.035	1.198
	Tumor size (mm)	0.004	0.025	0.027	0.891	−0.048	0.055	1.785
	Depth of invasion (mm)	0.038	0.041	0.166	0.364	−0.046	0.122	1.573
	Histology grade	−1.020	0.917	−0.185	0.274	−2.884	0.845	1.340
	Necrosis presence	0.510	1.300	0.062	0.697	−2.131	3.152	1.196
	Vascular invasion	−0.573	1.344	−0.067	0.673	−3.304	2.158	1.182
	Perineural invasion	−2.661	1.133	−0.382	0.025	−4.963	−0.359	1.282
	Extracapsular nodal extension	−0.183	2.271	−0.013	0.936	−4.798	4.432	1.303
	Stage	0.263	0.629	0.076	0.678	−1.015	1.541	1.598
	Smoking	3.056	1.546	0.319	0.056	−0.086	6.197	1.258
2	(Constant)	2.393	2.998		0.430	−3.693	8.480
	Sex: male	−0.456	1.183	−0.066	0.703	−2.858	1.947	1.456
	Age at diagnosis	−0.036	0.034	−0.161	0.301	−0.105	0.034	1.174
	Tumor size (mm)	0.004	0.025	0.029	0.875	−0.046	0.054	1.725
	Depth of invasion (mm)	0.038	0.041	0.165	0.359	−0.045	0.120	1.571
	Histology grade	−1.040	0.869	−0.189	0.240	−2.805	0.725	1.238
	Necrosis presence	0.499	1.274	0.060	0.698	−2.087	3.085	1.182
	Vascular invasion	−0.558	1.313	−0.065	0.673	−3.224	2.107	1.161
	Perineural invasion	−2.669	1.113	−0.383	0.022	−4.928	−0.409	1.273
	Stage	0.254	0.609	0.073	0.679	−0.983	1.491	1.544
	Smoking	3.070	1.514	0.320	0.050	−0.003	6.143	1.241
6	(Constant)	2.699	2.666		0.318	−2.693	8.091
	Age at diagnosis	−0.034	0.032	−0.150	0.306	−0.099	0.032	1.156
	Depth of invasion (mm)	0.048	0.032	0.211	0.139	−0.016	0.113	1.073
	Histology grade	−0.901	0.778	−0.163	0.254	−2.475	0.672	1.093
	Vascular invasion	−0.470	1.241	−0.055	0.707	−2.981	2.040	1.144
	Perineural invasion	−2.650	1.012	−0.381	0.013	−4.697	−0.603	1.161
	Smoking	2.804	1.314	0.292	0.039	0.146	5.461	1.031
7	(Constant)	2.845	2.609		0.282	−2.429	8.119
	Age at diagnosis	−0.036	0.031	−0.162	0.253	−0.099	0.027	1.100
	Depth of invasion (mm)	0.048	0.032	0.211	0.134	−0.016	0.112	1.073
	Histology grade	−0.922	0.768	−0.167	0.237	−2.473	0.629	1.088
	Perineural invasion	−2.747	0.969	−0.394	0.007	−4.705	−0.788	1.087
	Smoking	2.825	1.299	0.295	0.036	0.201	5.450	1.029

B, regression coefficient; SE, standard error; beta, standard regression coefficient; CI, confidence interval; VIF, variance inflation factor.