Table of Contents Author Guidelines Submit a Manuscript
Advances in Pharmacological Sciences
Volume 2009, Article ID 787586, 6 pages
http://dx.doi.org/10.1155/2009/787586
Research Article

Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

1Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 405 30 Göteborg, Sweden
2Department of Toxicology, Faculty of Military Health Sciences, University of Defence, 500 01 Hradec Kralove, Czech Republic

Received 27 January 2009; Revised 26 March 2009; Accepted 30 March 2009

Academic Editor: Mustafa F. Lokhandwala

Copyright © 2009 Anders T. Ryberg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Tobin, A. T. Ryberg, S. Gentle, and A. V. Edwards, “Distribution and function of muscarinic receptor subtypes in the ovine submandibular gland,” Journal of Applied Physiology, vol. 100, no. 4, pp. 1215–1223, 2006. View at Publisher · View at Google Scholar
  2. J. M. Lundberg, “Evidence for coexistence of vasoactive intestinal polypeptide (VIP) and acetylcholine in neurons of cat exocrine glands. Morphological, biochemical and functional studies,” Acta Physiologica Scandinavica, Supplement, vol. 496, pp. 1–57, 1981. View at Google Scholar
  3. E. M. Wathuta, “The distribution of vasoactive intestinal polypeptide-like, substance P-like and bombesin-like immunoreactivity in the digestive system of the sheep,” Quarterly Journal of Experimental Physiology, vol. 71, no. 4, pp. 615–631, 1986. View at Google Scholar
  4. A. M. Reid and L. H. Heywood, “A comparison of the effects of vasoactive intestinal polypeptde on secretion from the submaxillary gland of the sheep and pig,” Regulatory Peptides, vol. 20, no. 3, pp. 211–221, 1988. View at Publisher · View at Google Scholar
  5. S. J. Hanna and A. V. Edwards, “The role of nitric oxide in the control of protein secretion in the parotid gland of anaesthetized sheep,” Experimental Physiology, vol. 83, no. 4, pp. 533–544, 1998. View at Google Scholar
  6. C. M. B. Edwards, P. P. Corkery, and A. V. Edwards, “Submandibular responses to stimulation of the parasympathetic innervation in anesthetized sheep,” Journal of Applied Physiology, vol. 95, no. 4, pp. 1598–1605, 2003. View at Google Scholar
  7. J. Ekström and G. Tobin, “Secretion of protein from salivary glands in the ferret in response to vasoactive intestinal peptide,” Journal of Physiology, vol. 415, pp. 131–141, 1989. View at Google Scholar
  8. J. Ekström and G. Tobin, “Protein secretion in salivary glands of cats in vivo and in vitro in response to vasoactive intestinal peptide,” Acta Physiologica Scandinavica, vol. 140, no. 1, pp. 95–103, 1990. View at Publisher · View at Google Scholar
  9. J. Ekström, A. Asztély, and G. Tobin, “Parasympathetic non-adrenergic, non-cholinergic mechanisms in salivary glands and their role in reflex secretion,” European Journal of Morphology, vol. 36, supplement 2, pp. 208–212, 1998. View at Google Scholar
  10. J. Ekström, B. Mansson, and G. Tobin, “Vasoactive intestinal peptide evoked secretion of fluid and protein from rat salivary glands and development of supersensitivity,” Acta Physiologica Scandinavica, vol. 119, no. 2, pp. 169–175, 1983. View at Publisher · View at Google Scholar
  11. A. D. Buckle, S. J. Parker, S. R. Bloom, and A. V. Edwards, “The role of nitric oxide in the control of protein secretion in the submandibular gland of the cat,” Experimental Physiology, vol. 80, no. 6, pp. 1019–1030, 1995. View at Google Scholar
  12. O. Larsson, M. Dunér-Engström, J. M. Lundberg, B. B. Fredholm, and A. Änggård, “Effects of VIP, PHM and substance P on blood vessels and secretory elements of the human submandibular gland,” Regulatory Peptides, vol. 13, no. 3-4, pp. 319–326, 1986. View at Publisher · View at Google Scholar
  13. S. C. Martin and T. J. Shuttleworth, “The control of fluid-secreting epithelia by VIP,” Annals of the New York Academy of Sciences, vol. 805, pp. 133–147, 1996. View at Publisher · View at Google Scholar
  14. T. Kusakabe, H. Matsuda, Y. Gono et al., “Distribution of VIP receptors in the human submandibular gland: an immunohistochemical study,” Histology and Histopathology, vol. 13, no. 2, pp. 373–378, 1998. View at Google Scholar
  15. J. M. Lundberg, A. Änggård, and J. Fahrenkrug, “Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. III. Effects of local infusions,” Acta Physiologica Scandinavica, vol. 114, no. 3, pp. 329–337, 1982. View at Publisher · View at Google Scholar
  16. J. M. Lundberg, A. Änggård, and J. Fahrenbrug, “Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. II. Effects of cholinergic antagonists and VIP antiserum,” Acta Physiologica Scandinavica, vol. 113, no. 3, pp. 329–336, 1981. View at Publisher · View at Google Scholar
  17. G. Tobin, “Presynaptic muscarinic M1 and M2 receptor modulation of auriculotemporal nerve transmission in the rat,” Journal of the Autonomic Nervous System, vol. 72, no. 1, pp. 61–71, 1998. View at Publisher · View at Google Scholar
  18. G. Tobin, J. Ekström, S. R. Bloom, and A. V. Edwards, “Atropine-resistant submandibular responses to stimulation of the parasympathetic innervation in the anaesthetized ferret,” Journal of Physiology, vol. 437, pp. 327–339, 1991. View at Google Scholar
  19. G. Tobin, J. Ekström, R. Ekman, and R. Håkanson, “Influence of atropine on the depletion of vasoactive intestinal peptide, substance P and calcitonin gene-related peptide from rat parotid gland in response to parasympathetic nerve stimulation,” Acta Physiologica Scandinavica, vol. 150, no. 4, pp. 463–465, 1994. View at Publisher · View at Google Scholar
  20. J. M. Lundberg, A. Änggård, and J. Fahrenkrug, “Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. I. VIP release,” Acta Physiologica Scandinavica, vol. 113, no. 3, pp. 317–327, 1981. View at Publisher · View at Google Scholar
  21. M. P. Caulfield and N. J. M. Birdsall, “International union of pharmacology. XVII. Classification of muscarinic acetylcholine receptors,” Pharmacological Reviews, vol. 50, no. 2, pp. 279–290, 1998. View at Google Scholar
  22. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Google Scholar
  23. G. Tobin, “Presynaptic muscarinic receptor mechanisms and submandibular responses to stimulation of the parasympathetic innervation in bursts in rats,” Autonomic Neuroscience, vol. 99, no. 2, pp. 111–118, 2002. View at Publisher · View at Google Scholar
  24. G. D'Agostino, A. Barbieri, E. Chiossa, and M. Tonini, “M4 muscarinic autoreceptor-mediated inhibition of [H3]acetylcholine release in the rat isolated urinary bladder,” The Journal of Pharmacology and Experimental Therapeutics, vol. 283, no. 2, pp. 750–756, 1997. View at Google Scholar
  25. G. D'Agostino, M. L. Bolognesi, A. Lucchelli et al., “Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype,” British Journal of Pharmacology, vol. 129, no. 3, pp. 493–500, 2000. View at Publisher · View at Google Scholar
  26. P. Alberts, “Classification of the presynaptic muscarinic receptor subtype that regulates 3H-acetylcholine secretion in the guinea pig urinary bladder in vitro,” The Journal of Pharmacology and Experimental Therapeutics, vol. 274, no. 1, pp. 458–468, 1995. View at Google Scholar
  27. H. Kilbinger, R. Schneider, H. Siefken, D. Wolf, and G. D'Agostino, “Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea,” British Journal of Pharmacology, vol. 103, no. 3, pp. 1757–1763, 1991. View at Google Scholar
  28. A. T. Ryberg, H. Selberg, O. Soukup, K. Gradin, and G. Tobin, “Cholinergic submandibular effects and muscarinic receptor expression in blood vessels of the rat,” Archives of Oral Biology, vol. 53, no. 7, pp. 605–616, 2008. View at Publisher · View at Google Scholar
  29. A. T. Ryberg, G. Warfvinge, L. Axelsson, O. Soukup, B. Götrick, and G. Tobin, “Expression of muscarinic receptor subtypes in salivary glands of rats, sheep and man,” Archives of Oral Biology, vol. 53, no. 1, pp. 66–74, 2008. View at Publisher · View at Google Scholar
  30. T. Takeuchi, N. Yamashiro, T. Kawasaki, H. Nakajima, Y.-T. Azuma, and M. Matsui, “The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse,” Neuroscience, vol. 156, no. 2, pp. 381–389, 2008. View at Publisher · View at Google Scholar
  31. J. R. Garrett, “Innervation of salivary glands: neurohistological and functional aspects,” in The Salivary System, L. M. Sreebny, Ed., pp. 69–93, CRC Press, Boca Raton, Fla, USA, 1986. View at Google Scholar