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Advances in Pharmacological Sciences
Volume 2010, Article ID 730861, 10 pages
Review Article

A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction

Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, SL83, New Orleans, LA 70112-2699, USA

Received 27 April 2010; Accepted 3 June 2010

Academic Editor: Christoph H. Gleiter

Copyright © 2010 George F. Lasker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite.