The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion
Figure 2
Measurement of H2O2 (M) release from rat femoral veins during reperfusion in the saline control group and BH4- or BH2-treated group. (a) H2O2 (M) releases from rat sham and I/R femoral veins during reperfusion in the saline control group. Anesthetized rats were given saline via tail vein at the beginning of reperfusion There was a significant increase in H2O2 release from I/R veins compared to sham veins during reperfusion. ( from sham limb) (b) The relative difference in H2O2 release between I/R and sham femoral veins in the saline control group BH4 (6.5 mg/kg) treated group and BH2 (2 mg/kg) treated group BH4 or BH2 was given via tail vein at the beginning of reperfusion. BH4 treatment significantly decreased H2O2 release at 45-minute reperfusion compared to saline control. ( from saline control group).
