Advances in Pharmacological and Pharmaceutical Sciences / 2010 / Article / Fig 7

Research Article

The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury When Given at Reperfusion

Figure 7

Light microscopy photograph of hematoxylin and eosin-stained rat heart tissue from I/R+PMN and I/R+PMN+BH4 (10  M). (a)–(c), I/R+PMN heart illustrated enhanced PMN coronary vascular adherence and tissue infiltration ((a): 20x; (b): 40x; (c): 100x). (d)–(f), I/R+PMN+BH4 (10  M) heart exhibited a reduction in PMN coronary vascular adherence and tissue infiltration compared with I/R+PMN ((d): 20x; (e): 40x; (f): 100x). Arrows indicate infiltrated PMN and arrowheads indicate PMN adherence to coronary vasculature. Scale bar, 50  m.

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